Lady Gaga Will Perform Her First ‘ARTPOP’ Single LIVE At The 2013 MTV VMAs! Let’s Celebrate With Mother Monster’s 8 Best VMA Moments! (PHOTOS)

Lady Gaga opens the 2011 MTV Video Music Awards with a live performance of "You and I" as her alter-ego Jo Calderone.

6.) That time Lady Gaga was a guy named Jo: Opening the 2011 VMAs as her alter ego Jo Calderone, Gaga ranted on about her on-again/off-again relationship with herself/himself before launching into an epic live performance of  “Yoü and I” featuring Queen‘s Brian May on guitar.